Camptostemon philippinensis is one of the endemic tree species found in mangrove ecosystems in the Philippines. Its leaf extracts were tested for its antimelanogenic and antibacterial properties. The antimelanogenic property as determined using the zebrafish-based assay system, showed that C. philippinensis methanolic leaf extracts had a profound effect on the melanin production in the embryo by decreasing the pigmentation by >50% as compared to the control. Furthermore, C. philippinensis leaf extracts exhibited dose dependent inhibitory activity on ocular melanogenesis. At 175 µg/mL and 200 µg/mL, the anti-melanogenic property was comparable with that of the commercially available whitening agent, kojic acid. The antibacterial screening was conducted using diffusion disk assay method against Gram-positive Staphylococcus aureus, Bacillus subtilis, and Gram negative Escherichia coli and Pseudomonas aeruginosa. Its methanolic extractsinhibited only the grampositive bacteria. However, after further fractionation, its ethyl acetate (EtOAc) extract exhibited antibacterial activity against both gram-positive and gram negative bacteria. The minimum inhibitory concentration (MIC) for the EtOAc fraction was 0.31 ± 0.00 mg/mL for Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa, and 0.42 ± 0.18 mg/mL for Escherichia coli. As shown by the results of this study, C. philippinensis can be a potent source of compounds with antimelanogenic and antibacterial properties