The green mussel Perna viridis, is widely distributed and cultivated in the Philippines for commercial purposes or solely for subsistence consumption. Due to its tolerance to a wide range of environmental conditions, it can grow rapidly in dense colonies on a range of hard substrata. P. viridis cultured through longline and stake method, and those thriving in wild colonies in Leyte, Villareal and Cancabato Bays respectively were examined to provide data on the biological characteristics of this organism and its environmental conditions. Calculation of condition index (CI) revealed that green mussels in Cancabato Bay have the highest CI values (15.73% ± 5.95), followed closely by that in Leyte Bay (15.34% ± 2.37). Gross morphological examination of the mussels showed that females dominated the sex ratio throughout the sampling period in all bays (59% females: 41% males). Using Pearson’s correlation coefficient (P value < 0.05), combined data from the three bays showed a positive correlation on shell and meat dimensions with pH; as well as meat dry weight (MDW) and CI with dissolved oxygen (DO). However, a negative correlation on Meat Wet Weight (MWW), MDW, and CI with salinity was observed. Higher CI values in Leyte Bay than Villareal Bay imply that cultivated mussels grow better in longline method than in stake method. Further study is recommended to confirm these initial findings. This study can be used to better aquaculture strategies in the region.